After ITAM tyrosine phosphorylation, a complex containing Bruton’s tyrosine kinase (Btk), tyrosine kinase expressed in hepatocellular carcinoma (Tec), the adaptor molecules B cell linker protein (BLNK) and Src homology 2 domain-containing leukocyte protein of 76 kD (SLP76) is formed that facilitates cooperation between RANK and ITAM signaling [18]. Here, BTK is linked to hepatocellular carcinoma.