Although further studies are needed to delineate how the interaction of Sox7 mediated inhibition of -catenin/TCF/LEF-1 complex transcriptional activity, our findings collectively highlight the suppressive roles of Sox7 in Wnt/β-catenin signaling and its tumorigenic capacities in endometrial cancer cells carrying either wild-type or mutant β-catenin. The gene discussed is LEF1; the disease is endometrial cancer.