Figure 1 shows the distribution of plasma fibulin-1 concentrations in patients with chronic kidney disease in the absence and presence of diabetes mellitus as compared to age- and sex-matched control subjects without kidney disease and without diabetes (age, median 60 years, range 60 to 61; sex, 46 men, 77%; BMI, median 27.1 kg/m2, range 24.7 to 30.7; smoking, 21 participants, 35%). This evidence concerns the gene FBLN1 and chronic kidney disease.