FBLN1 and chronic kidney disease: Furthermore, we observed significantly increased fibulin-1 concentrations in patients with chronic kidney disease plus diabetes mellitus (median, 78 μg/mL; 74 to 113 μg/mL) compared to patients with chronic kidney disease without diabetes mellitus (median, 69 μg/mL; 49 to 79 μg/mL; p < 0.050).