IGHE and allergic disease: Human PBMC from one donor (non-AD1) who had no history of allergy displayed mean values of IgE of 200 ± 94 ng/ml (n = 6) in vitro, whereas hPBMC from the other donor (non-AD2) who experienced rare allergic reactions displayed mean IgE values of 275 ± 126 ng/ml (n = 4).