The analysis of CD4+ : CD8+ ratios revealed that the pattern was preserved (Figure 5) whereby the non-AD donor was markedly stimulated by IL-4 (No treatment, n = 6; IL-4, n = 11, IL-4  + Antagonist, n = 5), AD1 moderately stimulated (No treatment, n = 3; IL-4, n = 4, IL4 + Antagonist, n = 4) and AD2 not stimulated (IL-4, n = 7; IL4 + Antagonist, n = 5) by IL-4 and antagonist in vitro and in vivo. Here, CD4 is linked to Alzheimer disease.