ARNT and cancer: We found indeed that 8 of 93 BEDMRs were co-located with regions containing genes causally linked with cancer based on the Cancer Gene Sensus definition, but in fact this number could be larger since 47/93 of all BEDMRs and more interestingly 66% of the BEDMRs encompassed in a genic region (47/71) contained at least one gene reported previously in the literature as linked with cancer, e.g., PCDH family, SETDB1, ARNT, PRDX6, ADAMTS4, EGR1, CTNN1A, and genes involved in the chromatin structure such as histone gene families and remodeling factors.