CXXC5 and cancer: In Figure 4, we showed a BEDMR at the 5q31.2 locus, which is epigenetically silenced in most cancers and contains the protocadherin A,B,G family, reported to be potential tumor suppressor genes modulating the canonical Wnt pathway in Wilms’ tumor (Dallosso et al., 2009) and other cancer related genes such as EGR1, CTNN1A, and CXXC5.