In agreement with these findings, knockdown of XBP1 expression by small interfering RNA has minimal effects on cells' susceptibility to other flaviviruses such as JEV and DEN (Zhao and Ackerman, 2006), although IRE1-XBP1 pathway was activated during the two viruses infection, as evidenced by XBP1 mRNA splicing and protein expression, as well as induction of the downstream genes ERdj4, EDEM1, and p58(IPK) (Yu et al., 2006). Here, XBP1 is linked to infection.