Nevertheless, pathophysiology of BrS is complex and some authors as Coronel et al. and Frustaci et al. have reported three authentic SCN5A mutations associated with histological and/or angiographic findings consistent with ARVD/C in patients with BrS (Coronel et al., 2005; Frustaci et al., 2005), raising again the question of an overlap between BrS and localized forms ARVD/C (Perez Riera et al., 2005; Hoogendijk et al., 2010). The gene discussed is SCN5A; the disease is arrhythmogenic right ventricular cardiomyopathy.