The T-AOC of HCC tissues (T) was lower compared to that of non-tumor liver tissues (NT) (0.277±0.156 mmol/g protein in T vs. 0.325±0.065 mmol/g protein in NT; P<0.05) (Fig. 1A), and the activity of total SOD also tended to be significantly lower in T when compared with the NT (60.420±15.222 U/mg protein in T vs. 89.381±18.064 U/mg protein in NT; P<0.0001) (Fig. 1B). Here, SOD1 is linked to neoplasm.