GPT and alcohol dependence: On the other hand, while most of the clinical parameters, including age, gender, cirrhosis, HBV surface antigen (HBsAg) serological positivity, anti-HCV serological positivity, ascites, α-fetoprotein (AFP), alanine aminotransferase (ALT) and Child-Pugh classification, were not associated with KAP expression, alcoholism and AST showed a positive correlation with increased KAP expression in the tumor sections (higher T/N ratios).