Importantly, therefore, and supportive of a role for ES-62 stimulated IFNγ in protecting against OVA-induced airway inflammation, the OVA + ES-62 group of mice treated with neutralising anti-IFNγ antibodies showed elevated levels of neutrophil (Fig. 5A), macrophage (Fig. 5B) and lymphocyte (Fig. 5C) infiltration of the BALF relative to those treated with control IgG. Here, IFNG is linked to inflammation.