Osteopontin (OPN) is a matricellular protein that through interactions with its receptors, integrins α4β1, α9β1, αv (β1, β3, β5), and CD44 variants, participates in a wide range of physiologic and pathologic processes, including wound healing, bone turnover, tumor genesis, inflammation, and immune responses [14-17]. This evidence concerns the gene SPP1 and neoplasm.