Unlike the reported effect of the OPN SNP conferring predisposition to common diseases such as multiple sclerosis or systemic lupus erythematosus, four SNPs of the OPN gene (327T/C, 795C/T, 1128A/G, and 1284A/C) did not contribute to RA susceptibility in a Spanish population [39]. This evidence concerns the gene SPP1 and multiple sclerosis.