Immunoblots comparing normal tissue and cancer tissue revealed that ADAMTS-1 could be detected in four different bands: the 110 kDa band, which likely represents total protein; the 80 kDa, which may characterize the protease without the pro-domain or the activated form; and two smaller bands, which may correspond to activated ADAMTS-1 with additional proteolytic processing [23,24]. This evidence concerns the gene ADAMTS1 and cancer.