The location of mir-548 gene family members is detected in all human chromosomes except chromosomes 19 and Y and over 30% of the members are located in chromosomes 6, 8, and X. Furthermore, functionally miR-548 miRNAs are linked to various signaling pathways, including MARK, Wnt insulin, calcium, and p53 signaling pathways as well as to various cancers, including melanoma, colorectal, renal, small cell lung cancer, and glioma. This evidence concerns the gene INS and small cell lung carcinoma.