Our previous studies of RIS and CIS mitochondria [29,32] as well as spherule and pedicle mitochondria using ET [1] provided us with structural landmarks for comparison with lead-exposed, Bcl-xL transgenics, and lead-exposed Bcl-xL transgenics (Bcl-xL/lead) mitochondria. This evidence concerns the gene BCL2L1 and in situ carcinoma.