El Khoury et al. found that transgenic Tg2576 amyloid precursor protein transgenic mice (Tg2576), a model of Alzheimer disease-like pathology, is also deficient in CCR2 and these Tg2576 mice display reduced microglial accumulation around brain plaques [26]. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.