CPA4 and lung neoplasm: On the other hand, long arm of chromosome 7 possesses imprinted domain in 7q32-qter which including MEST1, MESTIT1, COPG2IT1loci and a group of four carboxypeptidase A (CPA) genes (CPA1, CPA2, CPA4, CPA5) [16], which are seem to be important (mainly MEST) in the initiation of breast and lung neoplasms [17].