In a study of 106 patients with metastatic colorectal cancer who had been treated with cetuximab and standard chemotherapy (only defined as irinotecan or oxaliplatin-based), Rodriguez et al. reported that patients with any FCGR2A 131H and/or FCGR3A 158 V allele were more likely to show a response or have stable disease (65% vs 35% for other genotypes; p = 0.014). This evidence concerns the gene FCGR2A and metastatic colorectal cancer.