Many studies have demonstrated that ACh and other components of cholinergic signaling, including ChAT, cholinesterase, M and N cholinergic receptors, are present in a variety of non-neuronal tissues, including most common cancer cells such as NSCLC, SCLC, colon, glial, breast and ovarian carcinomas. The gene discussed is BCHE; the disease is non-small cell lung carcinoma.