SPX further increased the infiltration of CD11c-positive and CD206-positive cells and the M1/M2 ratio in the intra-islet area in HF diet-fed mice (Figure 4A−D) and this was suppressed by IL-10 treatment (Figure 4A−D), suggesting that IL-10 may ameliorate SPX-induced inflammation in the pancreas. The gene discussed is MRC1; the disease is hydrops fetalis.