The HF diet increased infiltration of CD11c-positive cells (M1 macrophages) (Figure 4A and 4B) and CD206-positive cells (M2 macrophages) (Figure 4A and 4C), as well as the M1/M2 ratio (Figure 4D) in the intra-islet area compared to standard chow. This evidence concerns the gene MRC1 and hydrops fetalis.