The Hutchinson-Gilford progeria syndrome (HGPS) [13], [17] occurs, in most cases, through the de novo dominant LMNA p.G608G mutation, which results in the persistence of a truncated farnesylated prelamin A (lamin AΔ50, also called progerin) [18]. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.