In patients with acute myocardial infarction (AMI), PTX3 peaked in plasma sooner than CRP, 6–8 h from symptom onset [18] and, when measured with established markers including CRP, NT-proBNP and troponin-T, emerged as the only independent predictor of three-month mortality [19]. This evidence concerns the gene PTX3 and acute myocardial infarction.