Thus, in the present study the effect of two differentially-selective S1P agonists, FTY720 and BAF312, that have been tested clinically and deemed clinically efficacious were investigated in anesthetized and telemetry-instrumented rats at clinically-relevant plasma concentrations to dissect the S1P receptor subtypes responsible for acute bradycardia and hypertension in vivo. The gene discussed is MBTPS1; the disease is hypertensive disorder.