We thus speculate that haploinsufficiency or loss of function mutations of ADAP2 might affect MT stability and function of those cells, such as myocytes and neurons, in which the impairment of cytoskeleton organization, may lead to the onset of cardiovascular malformation and/or cognitive defects in NF1 microdeletion syndrome or in specific congenital diseases [5]. Here, ADAP2 is linked to Cognitive impairment.