Notably, collagen genes including COL1A1 (22.8-fold), COL1A2 (7.98-fold), COL3A1 (13.6-fold), COL4A1 (32.57-fold), COL4A2 (14.1-fold), COL4A4 (3.04-fold), COL5A1 (17.23-fold), COL5A2 (32.73-fold), COL6A1 (5.26-fold), COL6A2 (3.12-fold), COL6A3 (3.95-fold), and COL11A1 (6.48-fold), were all up-regulated in tumor tissues by qRT-PCR (Figure 3A). This evidence concerns the gene COL4A1 and neoplasm.