In our study, fibroblastic meningioma was detected with increasing expression of CCND1, CDK6, and E2F3, and decreasing expression of CDKs inhibitors including CDKN1A, CDKN2A, and CDKN2B, suggesting a role of cell cycle deregulation in the tumorigenesis of fibroblastic meningioma. The gene discussed is E2F3; the disease is meningioma.