Regarding downstream gene cascades of Akt, apoptosis-induced genes including CASP9 (3.78-fold), CDKN1A (8.64-fold), AXIN2 (2.78-fold), APC2 (3.12-fold), and EP300 (5.35-fold) were detected with significant down-regulation in fibroblastic meningiomas (Figure 2B). This evidence concerns the gene EP300 and meningioma.