For example, physiological levels of NO have been reported to attenuate: IL-2-induced lung injury in rats [26]; phorbol ester-induced microvascular permeability in dogs [27] and hydrogen peroxide-induced vascular permeability in rabbits [28]; leukocyte adhesion and vascular leak after myocardial ischemia [29]; platelet aggregation and adherence to sites of injury on endothelial cells [30], [31], [32], [33], [34], [35]; upregulation of cell adhesion molecules (CAM) on endothelial cells [36], [37], [38], [39]; and vascular smooth muscle cell proliferation and migration [40], [41], [42]. This evidence concerns the gene IL2 and myocardial ischemia.