In our assessment of the prognostic value of serum albumin concentration in head and neck cancer patients with liver cirrhosis, we demonstrated that preoperative serum albumin concentration ≤ 3.5 mg/dL as well as POD1 albumin concentration ≤ 2.7 mg/dL was an independent predictor of postoperative medical complication and mortality. The gene discussed is ALB; the disease is cirrhosis of liver.