ADD1 and peripheral arterial disease: For example, the Trp460 ADD1 allele is associated with higher systolic and diastolic blood pressure [173], with increased incidence of peripheral arterial disease (PAD) and coronary heart disease (CHD) [174], increased carotid artery intima-media thickness (IMT) [175], [176], increased risk of stroke [176], and reduced acetylcholine-stimulated forearm blood flow (FBF) response via an impaired endothelium-dependent vasodilation [177].