First, previous studies have established ROR1 as a survival kinase [22], [31], [32] or pseudokinase [33] whose silencing with siRNA significantly interferes with in vitro and ex vivo survival of cell lines and primary cells, including primary B-ALL blasts from E2A-PBX1+ ROR1+ patients [20]. The gene discussed is ROR1; the disease is acute lymphoblastic leukemia.