Biallelic or in the case of FA-B hemizygous mutations in any one of the underlying genes lead to FA, while monoallelic mutations in FANCD1 (BRCA2), FANCJ (BRIP1), FANCN (PALB2) or FANCO (RAD51C) increase the risk of carriers for developing breast and ovarian cancer [1]. Here, PALB2 is linked to ovarian cancer.