Biallelic or in the case of FA-B hemizygous mutations in any one of the underlying genes lead to FA, while monoallelic mutations in FANCD1 (BRCA2), FANCJ (BRIP1), FANCN (PALB2) or FANCO (RAD51C) increase the risk of carriers for developing breast and ovarian cancer [1]. This evidence concerns the gene PALB2 and Friedreich ataxia.