Moreover, we evaluated the gene and protein expression levels of CF in the corpus callusom of adenosine A2A receptor gene knockout (KO) and wild-type (WT) mice and WT mice treated with the A2A receptor agonist CGS21680 or both CGS21680 and A2A receptor antagonist SCH58261. The gene discussed is ADORA2A; the disease is cystic fibrosis.