ADORA2A and spindle cell hemangioma: Our study also revealed that the CF mRNA and protein levels in the corpus callosum in the CGS+SCH group were strikingly increased compared with those in the WC group, which indicated that the adenosine A2A receptor antagonist SCH58261 counteracted the down-regulation of cystatin F expression produced by the A2A receptor agonist CGS21680 after chronic cerebral hypoperfusion and confirmed that the effect of CGS21680 on CF expression acted through activation of the adenosine A2A receptor.