In the present study, PVN microinjection of Ang II and Ang-(1-7) at the same time also caused greater enhancing effects on RSNA, MAP and CSAR than Ang II or Ang-(1-7) alone in 2K1C rats but not in Sham rats, suggested that there also exists a synergetic effect of Ang II and Ang-(1-7) in the PVN in enhancing the CSAR and sympathetic outflow in renovascular hypertensive rats. Here, ANG is linked to renovascular hypertension.