It was reported that following influenza infection, antigen-presenting cells secrete IL-10, which contributes to the differentiation of Th0 cells into Th2 cells; subsequently, Th2 cells secrete IL-4, IL-5, and IL-6, which help to preferentially drive IgG1, IgA, and IgE antibody production by antibody-secreting plasma cells [49]. The gene discussed is IGHE; the disease is influenza.