MPO and metabolic dysfunction-associated steatotic liver disease: To investigate if the marked reduction of hepatic MPO in LDLR−/−/MPO−/−tp mice translated into diminished generation of MPO-mediated cytotoxic products, we studied hepatic levels of nitrotyrosine, a protein modification generated at sites of inflammation as a result of the activity of several enzymes among which MPO, which accumulates in NAFLD [5], [8], [23].