To determine the mechanism by which miR-204 may exhibit its tumor growth and metastasis suppressor activity, we examined the effect of miR-204 on AKT/mTOR signaling as both BDNF and Ezrin have been shown to activate AKT pathway [27], and selective activation of AKT by mTOR has been shown to regulate cancer cell migration and invasion [28]. Here, AKT1 is linked to cancer.