Although the minor allele of the rs17782313 (T>C), has also been significantly associated with greater BMI [2], [4], [9]–[11], its relevance in terms of the magnitude of the association is considered smaller than that of FTO polymorphism, being the per-allele OR for obesity of 1.12 (95% CI: 1.08–1.16) in the initial meta-analysis [2]. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.