In the fully adjusted model (sex, age, center, diabetes, total energy intake and physical activity, each variant allele (FTO or MC4R) of the additive score increased the odds of obesity by 7% (OR = 1.07; 95%CI: 1.01–1.13) for the continuous aggregate score variable). The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.