Thus, when physical activity was low, the FTO polymorphism and the aggregate score were significantly associated with higher obesity risk in carriers of the variant allele (a 17% per-allele increase; 95%CI: 7–27 and a 12% per-allele increase; 95%CI: 5–20 in the OR of obesity, respectively). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.