PMAIP1 and hepatocellular carcinoma: Together with the observation that ABT-737 synergistically induces apoptosis with overexpression of Noxa that destabilizes or inhibits Mcl-1 [34], we were inspired to explore new treatment regimen(s) taking advantage of the antagonist effect of Noxa to Mcl-1, so as to improve the therapeutic outcome of HCC patients.