BDNF and mood disorder: It is likely that stress may have an adverse impact on the IVF outcome in spite of a new meta-analysis which contradicts this opinion [34].Our current studies indicate that supplement with intraovarian endocrine/paracrine regulators, such as BDNF, may be beneficial for oocytes developments when gonadotropin is used to hyperstimulate ovaries in women with chronic stress or mood disorder.