The AST enzyme in dengue patients with warning signs was raised throughout the illness, and this enzyme was associated (i) at the febrile phase- ICAM-1, FGF-Basic, IL-13, IL-4, IL-12 and VEGF; (ii) defervescence: PDGF and (iii) convalescence- IFN-γ and IP-10. The gene discussed is CXCL10; the disease is dengue disease.