Recently, our group also discovered a new small molecule named Inauhzin (INZ), which induces the level and activity of wide-type p53 by inhibiting Sirt1 activity and also represses the growth of tumors derived from human lung non-small cell carcinoma H460 and colon cancer HCT116 cells in a p53-dependent fashion [17]. Here, TP53 is linked to colonic neoplasm.