KCNMA1 and Parkinson disease: They are activated under ischemic stresses such as glucose deprivation and thus regulating them using BK channel openers such as NS1619 [32], [44], or altering levels of intracellular calcium or high-energy phosphates, may protect basal ganglial function and relieve symptoms in patients with strategic infarct dementia and Parkinsonism due to cerebrovascular disease.