CCN2 and myocardial infarction: In this study we therefore investigated the role of CTGF in post-MI remodeling of the left ventricle both in an animal model of myocardial infarction and in a cohort of patients admitted for first-time, acute ST-elevation MI (STEMI) treated by primary PCI, and assessed with cardiac MRI and analysis of s-CTGF levels at several time points after the acute event.