In conclusion, the congruent findings of attenuated LV remodeling after MI in mice with cardiac-restricted overexpression of CTGF as well as in patients that respond with increased s-CTGF levels after MI, support a beneficial role of CTGF in LV remodeling and functional recovery of the heart after MI mediated by attenuation of inflammatory responses and inhibition of apoptosis. Here, CCN2 is linked to myocardial infarction.