The slight increase of microvessel density in the peri-infarct region of Tg-CTGF mice 4 weeks after MI compared with that of NLC mice is consistent with a previous report from our laboratory, demonstrating increased microvessel densities in myocardial tissue of Tg-CTGF mice not subjected to myocardial infarction [7]. The gene discussed is CCN2; the disease is myocardial infarction.