In addition to these experimental proofs, Yan-et al recently elegantly demonstrated that HMGB1 levels are associated with angiographically significant CAD both in nondiabetic and in type 2 diabetic patients in a large patient cohort (n = 512) [24], whereas we previously showed that a close association is present between HMGB1 and infarct size in patients with acute coronary syndromes [9], [10]. Here, HMGB1 is linked to acute coronary syndrome.