PPF was increased in saline-treated 3xTg-AD mice (t (1, 7) = −2.63, p<0.05, Figure 4A) with acute RyR inhibition, while sub-chronic dantrolene treatment completely reversed the RyR-mediated increases in PPF in these mice (p>0.05, Figure 4B), normalizing this response to that of NonTg mice. This evidence concerns the gene RYR2 and Alzheimer disease.