Oules et al., 2012 (25) and Peng et al., 2012 (24) demonstrate a marked improvement in cognitive function and amyloid load in AD mice with chronic systemic treatment with dantrolene, and experiments in neuronal cell cultures exposed to dantrolene suggest that the reduced amyloid is likely mediated by reductions in APP phosphorylation and β- and γ-secretase activity (25). This evidence concerns the gene PPIB and Alzheimer disease.