RYR2 and Alzheimer disease: We found that both 3xTg-AD and TASTPM mice treated 4 weeks with dantrolene had RyR2 mRNA levels that were no different from saline-treated NonTg mice, and were significantly lower than the saline-treated AD-Tg mice of their respective strain (F (3,22) = 10.6; p<0.05: F(3,18) = 4.15; p<0.05 for 3xTg-AD and TASTPM respectively).