Synphilin-1 is linked to the pathogenesis of Parkinson disease by its presence in Lewy bodies [61], its interaction with α-synuclein, a key protein of PD, its relation to the UPS both as a substrate and a mediator of degradation [14], [16], [62], and its involvement in synaptic vesicle trafficking [63]. This evidence concerns the gene SNCAIP and Parkinson disease.