Additionally, although literature directly addressing phenotypic changes of lung macrophages during infection is limited [29], we show here that a population of CD11b+/CD11c+ cells comprised of both previously CD11b−/CD11c+ long-term resident and comparatively newly resident previously CD11b+/CD11c- cells exists within the alveolus of the lung directly following C. burnetii infection (Figure 3). Here, ITGAX is linked to infection.