In this section, besides alpha-1B-glycoprotein (A1BG) and Leucine-rich alpha-2-glycoprotein (LRG1) which are of mid-range abundance in the serum, we chose a low abundant serum protein ubiquitin carboxyl-terminal hydrolase 1 (USP1) that was detected in NSCLC sera. Here, LRG1 is linked to non-small cell lung carcinoma.