NOS2 and Sepsis: Finally, statins increase the physiologic concentrations of nitric oxide (NO) by increasing the expression of endothelial NO synthase and down-regulating inducible NO synthase, and thus reverse the endothelial dysfunction in sepsis [12].These pleiotropic effects of statins have been demonstrated in experimental models (in vitro and in vivo), and some [13]–[15] but not all studies [4], [6], [7], [16], [17] showed serendipitous benefits of statins to patients with severe infections, such as sepsis and COPD.