As demonstrated by the normalized composite of 11 different experiments (Figure 5A), CLL-primed UCB T-cells exhibited a significant increase in IFN-γ ELISpots when co-cultured with CLL stimulators in comparison to co-culture with HLA-identical CD8+ stimulators (average of all 9 experiments: 20.3%+/−21.2%, p<0.02 by pair-wise t-test), indicating distinct, CLL–specific (or at least B-lineage specific) responses. Here, CD8A is linked to B-cell chronic lymphocytic leukemia.