SNPs analyzed in relation to overall bladder cancer risk that we reported previously (e.g. in metabolism SNPs methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 (MTHFD2), alcohol dehydrogenase 1C (ADH1C); telomerase SNPs telomerase-associated protein 1 (TEP1) and telomerase reverse transcriptase (TERT)) also met the current criteria for statistical significance, false discovery rate, and minimum sample size per cell that we set for this restricted analysis of urothelial cell carcinoma risk and showed similar trends for risk of both non-invasive and invasive tumors [18]. This evidence concerns the gene MTHFD2 and transitional cell carcinoma.