Recent studies have revealed that ablation of RXRα and RXRβ in adult murine keratinocytes leads to an AD-like phenotype triggered by induction of TSLP [13].Similarly, TSLP is also elevated in Notch signaling-deficient keratinocytes (deficient in either Notch1/2 or recombining binding protein suppressor of hairless (RBP-j) [12], [13], [32]. The gene discussed is NOTCH1; the disease is Alzheimer disease.